![Phosphorylation promotes binding affinity of Rap-Raf complex by allosteric modulation of switch loop dynamics | Scientific Reports Phosphorylation promotes binding affinity of Rap-Raf complex by allosteric modulation of switch loop dynamics | Scientific Reports](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41598-018-31234-7/MediaObjects/41598_2018_31234_Fig1_HTML.png)
Phosphorylation promotes binding affinity of Rap-Raf complex by allosteric modulation of switch loop dynamics | Scientific Reports
![Frontiers | The Multi-Level Mechanism of Action of a Pan-Ras Inhibitor Explains its Antiproliferative Activity on Cetuximab-Resistant Cancer Cells Frontiers | The Multi-Level Mechanism of Action of a Pan-Ras Inhibitor Explains its Antiproliferative Activity on Cetuximab-Resistant Cancer Cells](https://www.frontiersin.org/files/Articles/625979/fmolb-08-625979-HTML/image_m/fmolb-08-625979-g001.jpg)
Frontiers | The Multi-Level Mechanism of Action of a Pan-Ras Inhibitor Explains its Antiproliferative Activity on Cetuximab-Resistant Cancer Cells
![Biomolecules | Free Full-Text | Hyperactivated RAGE in Comorbidities as a Risk Factor for Severe COVID-19—The Role of RAGE-RAS Crosstalk Biomolecules | Free Full-Text | Hyperactivated RAGE in Comorbidities as a Risk Factor for Severe COVID-19—The Role of RAGE-RAS Crosstalk](https://www.mdpi.com/biomolecules/biomolecules-11-00876/article_deploy/html/images/biomolecules-11-00876-g001.png)
Biomolecules | Free Full-Text | Hyperactivated RAGE in Comorbidities as a Risk Factor for Severe COVID-19—The Role of RAGE-RAS Crosstalk
A New Dimension to Ras Function: A Novel Role for Nucleotide-Free Ras in Class II Phosphatidylinositol 3-Kinase Beta (PI3KC2β) Regulation | PLOS ONE
![The Importance of Mg2+‐Free State in Nucleotide Exchange of Oncogenic K‐Ras Mutants - Pálfy - Chemistry – A European Journal - Wiley Online Library The Importance of Mg2+‐Free State in Nucleotide Exchange of Oncogenic K‐Ras Mutants - Pálfy - Chemistry – A European Journal - Wiley Online Library](https://chemistry-europe.onlinelibrary.wiley.com/cms/asset/8b5bc56a-b6c8-4bbb-8909-93a898ce613d/chem202201449-toc-0001-m.jpg)
The Importance of Mg2+‐Free State in Nucleotide Exchange of Oncogenic K‐Ras Mutants - Pálfy - Chemistry – A European Journal - Wiley Online Library
![BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions | eLife BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions | eLife](https://iiif.elifesciences.org/lax/37122%2Felife-37122-fig1-v2.tif/full/1500,/0/default.jpg)
BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions | eLife
![RCSB PDB - 1U8Y: CRystal structures of Ral-GppNHp and Ral-GDP reveal two novel binding sites that are also present in Ras and Rap RCSB PDB - 1U8Y: CRystal structures of Ral-GppNHp and Ral-GDP reveal two novel binding sites that are also present in Ras and Rap](https://cdn.rcsb.org/images/structures/1u8y_assembly-1.jpeg)
RCSB PDB - 1U8Y: CRystal structures of Ral-GppNHp and Ral-GDP reveal two novel binding sites that are also present in Ras and Rap
![Cancers | Free Full-Text | Cutting the Brakes on Ras—Cytoplasmic GAPs as Targets of Inactivation in Cancer Cancers | Free Full-Text | Cutting the Brakes on Ras—Cytoplasmic GAPs as Targets of Inactivation in Cancer](https://www.mdpi.com/cancers/cancers-12-03066/article_deploy/html/images/cancers-12-03066-g001-550.jpg)
Cancers | Free Full-Text | Cutting the Brakes on Ras—Cytoplasmic GAPs as Targets of Inactivation in Cancer
![The current state of the art and future trends in RAS-targeted cancer therapies | Nature Reviews Clinical Oncology The current state of the art and future trends in RAS-targeted cancer therapies | Nature Reviews Clinical Oncology](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41571-022-00671-9/MediaObjects/41571_2022_671_Fig1_HTML.png)
The current state of the art and future trends in RAS-targeted cancer therapies | Nature Reviews Clinical Oncology
![The Activation of RalGDS Can Be Achieved Independently of Its Ras Binding Domain: IMPLICATIONS OF AN ACTIVATION MECHANISM IN Ras EFFECTOR SPECIFICITY AND SIGNAL DISTRIBUTION - ScienceDirect The Activation of RalGDS Can Be Achieved Independently of Its Ras Binding Domain: IMPLICATIONS OF AN ACTIVATION MECHANISM IN Ras EFFECTOR SPECIFICITY AND SIGNAL DISTRIBUTION - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0021925819363732-gr1.jpg)
The Activation of RalGDS Can Be Achieved Independently of Its Ras Binding Domain: IMPLICATIONS OF AN ACTIVATION MECHANISM IN Ras EFFECTOR SPECIFICITY AND SIGNAL DISTRIBUTION - ScienceDirect
![Integrated RAS signaling defined by parallel NMR detection of effectors and regulators | Nature Chemical Biology Integrated RAS signaling defined by parallel NMR detection of effectors and regulators | Nature Chemical Biology](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fnchembio.1435/MediaObjects/41589_2014_Article_BFnchembio1435_Fig1_HTML.jpg)
Integrated RAS signaling defined by parallel NMR detection of effectors and regulators | Nature Chemical Biology
![Binding of active Ras and its mutants to the Ras binding domain of PI-3-kinase: A quantitative approach to KD measurements - ScienceDirect Binding of active Ras and its mutants to the Ras binding domain of PI-3-kinase: A quantitative approach to KD measurements - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0003269722004791-ga1.jpg)
Binding of active Ras and its mutants to the Ras binding domain of PI-3-kinase: A quantitative approach to KD measurements - ScienceDirect
![Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange | PNAS Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange | PNAS](https://www.pnas.org/cms/10.1073/pnas.1315798111/asset/64e9dd1f-4465-42b3-995c-64e912772ed4/assets/graphic/pnas.1315798111fig03.jpeg)
Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange | PNAS
![Mapping the functional versatility and fragility of Ras GTPase signaling circuits through in vitro network reconstitution | eLife Mapping the functional versatility and fragility of Ras GTPase signaling circuits through in vitro network reconstitution | eLife](https://iiif.elifesciences.org/lax/12435%2Felife-12435-fig2-v2.tif/full/,1500/0/default.jpg)